ISOBOLOGRAPHIC ASSESSMENT OF INTERACTIONS BETWEEN RETIGABINE AND PHENYTOIN IN THE MOUSE MAXIMAL ELECTROSHOCK-INDUCED SEIZURE MODEL AND CHIMNEY TEST
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چکیده
منابع مشابه
Gabapentin synergistically interacts with topiramate in the mouse maximal electroshock seizure model: an isobolographic analysis.
The anticonvulsant effects produced by topiramate (TPM) and gabapentin (GBP)--two second-generation antiepileptic drugs, in numerous fixed-ratio combinations of 8:1, 4:1, 2:1, 1:1, 1:2, 1:4 and 1:8 were examined by isobolographic analysis in the mouse maximal electroshock seizure (MES) model. Results indicate that the combinations of TPM and GBP at the fixed-ratios of 2:1, 1:1, 1:2, 1:4 and 1:8...
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Experimental Evaluation of Median Effective Dose of Retigabine (trobalt ® ) in the Maximal Electroshock Test and Maximal Pentylenetetrazole Test in Rats
Retigabine is a novel antiepileptic drug that influences M-type potassium currents. It is active in broad range of animal seizure models. PURPOSE. The aim of the present study is to determine the median effective dose (ED50) of Retigabine in two seizure models – maximal electroshock (MES) test and maximal pentylenetetrazole (MPTZ) test in rats. METHODS. Male Wistar rats (10 groups of 6 rats) we...
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ژورنال
عنوان ژورنال: Health Problems of Civilization
سال: 2016
ISSN: 2353-6942
DOI: 10.5114/hpc.2016.63572